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Published on: April 29, 2013
Specificity and sensitivity of automated external defibrillator rhythm analysis in infants and children
Elizabeth Atkinson1, Bridget Mikysa, Jeffrey A Conway
1Department of Emergency Medicine, Indiana University, Indianapolis, IN, USA.
Insights
Automated external defibrillator (AED) algorithms, designed for adults, show high accuracy in identifying shockable rhythms in infants and children. This study confirms their effectiveness with both anterior-posterior and sternal-apex lead placements.
Area of Science:
- Pediatric Critical Care
- Cardiology
- Biomedical Engineering
Background:
- Automated external defibrillator (AED) algorithms are primarily based on adult data.
- The efficacy of AEDs in discriminating pediatric shockable rhythms is not well-established.
- Lead placement strategies (anterior-posterior vs. sternal-apex) may influence AED performance in children.
Purpose of the Study:
- To evaluate the performance of a specific AED algorithm in pediatric patients.
- To assess the algorithm's accuracy in differentiating shockable from nonshockable rhythms in infants and children.
- To compare the AED algorithm's effectiveness using anterior-posterior versus sternal-apex lead configurations.
Main Methods:
- Pediatric patients in critical care, electrophysiology, and cardiac operating rooms were enrolled.
- ECGs were recorded using standard defibrillation pads and analyzed by a LIFEPAK 500 AED.
- AED decisions were compared against expert clinician classifications of shockable/nonshockable rhythms to determine sensitivity and specificity.
Main Results:
- The AED demonstrated high sensitivity (99%) for coarse ventricular fibrillation and high specificity (99.5%) for nonshockable rhythms in 1,561 pediatric rhythm samples.
- Specificity remained high with both sternal-apex (99.1%) and anterior-posterior (99.4%) lead placements.
- The algorithm performed accurately across a wide pediatric age range (birth to 7 years).
Conclusions:
- The evaluated AED algorithm exhibits high sensitivity and specificity in pediatric populations.
- Both sternal-apex and anterior-posterior lead placements are effective for AED use in infants and children.
- This supports the reliable use of this AED algorithm in pediatric emergency care.
Study Objectives:
The rhythm detection algorithms of automated external defibrillators have been derived from adult rhythms, and their ability to discriminate between shockable and nonshockable rhythms in children is largely unknown. This study evaluates the performance of 1 automated external defibrillator algorithm in infants and children and evaluates algorithm performance with anterior-posterior versus sternal-apex lead placement.
Methods:
We enrolled pediatric patients in a critical care unit, an electrophysiology laboratory, and a cardiac operating room. A monitor-defibrillator recorded ECGs by means of standard defibrillation-monitor pads. Selected 15-second rhythm samples were played into a LIFEPAK 500 automated external defibrillator, and the automated external defibrillator "shock/no shock" decision was documented. To determine sensitivity and specificity, the automated external defibrillator decision was compared with the "shockable" versus "nonshockable" rhythm classification provided by 3 expert clinicians who were blinded to the automated external defibrillator decision.
Results:
We recorded 1,561 rhythm samples from 203 pediatric patients (median age 11 months; range, day of birth to 7 years). The automated external defibrillator recommended a shock for 72 of 73 rhythm samples classified as coarse ventricular fibrillation by expert review (sensitivity 99%; 95% confidence interval [CI] 93% to 100%); and correctly reached a "no shock advised" decision for 1,465 of 1,472 rhythm samples classified as nonshockable by experts (specificity 99.5%). Specificity was 99.1% (95% CI 97.8% to 99.8%) with the sternal-apex lead and 99.4% (95% CI 98.1% to 99.9%) with the anterior-posterior lead.
Conclusion:
This automated external defibrillator algorithm has high specificity and sensitivity when used in infants and children with either sternal-apex or anterior-posterior lead placement.
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