Related Experiment Videos
Epileptic seizure after stroke in Chinese patients
Chun-Ming Cheung1, Tak-Hong Tsoi, Man Au-Yeung
1Department of Medicine, Pamela Youde Nethersole Eastern Hospital, 3 Lok Man Road, Chai Wan, Hong Kong. chun-ming@graduate.hku.hk
Insights
Post-stroke seizures affect 3.4% of patients. Being male and having a cortical stroke location are independent risk factors for developing seizures after a stroke.
Area of Science:
- Neurology
- Epidemiology
Background:
- Post-stroke seizures (PSS) are a common complication following acute stroke.
- Identifying risk factors for PSS is crucial for patient management and prognosis.
Purpose of the Study:
- To determine the incidence rate of post-stroke seizures.
- To identify independent risk factors associated with PSS in a hospital-based cohort.
Main Methods:
- Retrospective review of 1000 consecutive patients in an acute stroke registry over one year.
- Data collected included demographics, seizure characteristics, treatment, and neuroimaging findings.
- Statistical analyses included univariate and multivariate logistic regression.
Main Results:
- 3.4% of patients developed seizures within one year post-stroke.
- Male sex (adjusted OR 3.21) and cortical location (adjusted OR 3.83) were significant independent risk factors for PSS.
- Early seizures were predominantly partial, while late seizures were often generalized tonic-clonic.
Conclusions:
- The incidence of PSS in this cohort is comparable to previous studies.
- Male gender and cortical stroke location are key predictors of PSS.
- Intracerebral and subarachnoid hemorrhage were not identified as risk factors in this study.
Abstract:
This was a hospital-based cohort study aiming at determining the occurrence rate of post-stroke seizures and the associated risk factors. From 27 July 1996 to 16 June 1998, the first 1000 consecutive patients in the acute stroke registry were retrospectively reviewed for one year after acute stroke to identify seizure occurrence. The demographic data, seizure onset time, seizure type, drug treatment, response to medication, electroencephalogram findings and cranial computed tomogram findings were collected. Thirty-four patients (3.4%) developed seizure within one year after acute stroke. Univariate analysis revealed that male, age greater than 65 years, total anterior circulation infarction, partial anterior circulation infarction, cortical location and large lesion were significantly associated with post-stroke seizure while multivariate analysis showed that only male (adjusted OR 3.21, p<0.01) and cortical location (adjusted OR 3.83, p<0.05) were significant independent risk factors. Fifty-six percent of early seizures were partial type whereas 72% of late seizures were generalized tonic-clonic type of undetermined onset. Seizures occurred in 3.4% of patients within one year after the onset of stroke. This percentage of seizure occurrence and associated risk factors were similar to other studies. However, intracerebral and subarachnoid haemorrhage were not shown to be risk factors in our study.