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Post-natal corticosteroid use
Olivia Williams1, Anne Greenough
1Children Nationwide Regional Neonatal Intensive Care Unit, Department of Child Health, Kings College Hospital, SE5 9RS London, UK.
European Journal of Pediatrics
|July 29, 2003
Summary
Systemic corticosteroids for newborns may reduce chronic lung disease (CLD) and mortality. However, prescribing practices vary widely, highlighting the need for a consensus on optimal corticosteroid regimens.
Area of Science:
- Neonatal medicine
- Pharmacology
Background:
- Systemic corticosteroids in early neonatal life may reduce chronic lung disease (CLD) and mortality.
- Concerns about long-term adverse effects might influence current prescribing habits.
Purpose of the Study:
- To assess current corticosteroid prescribing practices in UK neonatal units.
- To determine if a consensus exists on the appropriate regimen for corticosteroid use.
Main Methods:
- A questionnaire survey was sent to consultant pediatricians at 223 UK neonatal units.
- The survey collected data on route, timing, dosage, and indications for corticosteroid administration.
Main Results:
- A 72% response rate was achieved.
- 33% of respondents never prescribed steroids, and 3.75% used inhaled steroids only.
- Significant variation was observed in timing, dosage (ranging from <0.1 mg/kg/day to 0.5 mg/kg/day), and indications (primarily ventilator-dependent infants).
Conclusions:
- Wide variations in corticosteroid usage exist among UK neonatal units.
- There is a need to establish a corticosteroid dosage regimen with a favorable risk/benefit ratio.