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Cell Squeezing as a Robust, Microfluidic Intracellular Delivery Platform
Published on: November 7, 2013
Innovations in oligonucleotide drug delivery
Melanie A Lysik1, Susanna Wu-Pong
1Midwestern University, College of Pharmacy-Glendale, Department of Pharmaceutical Sciences, 19555 N 59th Avenue, Glendale, Arizona 18308, USA. mlysik@Arizona.midwester.edu
Journal of Pharmaceutical Sciences
|July 29, 2003
Summary
Oligonucleotides show therapeutic promise but face delivery challenges. This review explores innovative delivery methods to enhance oligonucleotide uptake, efficacy, and cost-effectiveness for treating diseases like cancer and HIV.
Area of Science:
- Biotechnology
- Drug Delivery
- Molecular Therapeutics
Background:
- Oligonucleotides (ONs) are emerging therapeutic agents for diseases including cancer and HIV.
- Poor cellular uptake and unclear uptake mechanisms limit ON efficacy.
- Existing delivery methods often bypass endocytosis to improve targeting and stability.
Purpose of the Study:
- To review traditional and novel delivery mechanisms for oligonucleotides.
- To highlight strategies for enhancing cellular delivery and therapeutic efficacy.
- To discuss improvements in cost-effectiveness for oligonucleotide-based therapies.
Main Methods:
- Review of scientific literature on oligonucleotide delivery systems.
- Analysis of various traditional and novel delivery approaches.
- Examination of methods to overcome cellular barriers to ON uptake.
Main Results:
- Delivery vehicles can significantly improve cellular uptake of oligonucleotides.
- Targeted delivery systems enhance specificity and drug stability.
- Novel strategies offer potential for improved therapeutic outcomes and cost-efficiency.
Conclusions:
- Effective delivery is crucial for realizing the therapeutic potential of oligonucleotides.
- Advancements in delivery mechanisms are key to overcoming current limitations.
- Optimized delivery strategies will broaden the application of ONs in medicine.
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