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Related Experiment Videos

Ascorbic acid and infertility treatment.

I Crha1, D Hrubá, P Ventruba

  • 1Department of Gynaecology and Obstetrics, Faculty of Medicine, Masaryk University, Obilní trh 11, 602 00 Brno, Czech Republic.

Central European Journal of Public Health
|July 30, 2003
PubMed
Summary

Vitamin C supplementation increased ascorbic acid levels in follicular fluid for women undergoing in vitro fertilization. While not significantly boosting overall pregnancy rates, it showed a greater impact in non-smokers.

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Area of Science:

  • Reproductive Endocrinology and Infertility
  • Nutritional Biochemistry

Background:

  • Ascorbic acid (vitamin C) plays a role in reproductive health.
  • Its levels in follicular fluid may influence in vitro fertilization (IVF) outcomes.
  • Smoking is known to negatively impact fertility and antioxidant levels.

Purpose of the Study:

  • To measure ascorbic acid levels in follicular fluid of women undergoing IVF/ET.
  • To evaluate the effect of vitamin C supplementation on IVF/ET treatment results.
  • To analyze the influence of smoking status on these outcomes.

Main Methods:

  • Prospective study involving 76 women undergoing IVF/ET, divided into smokers and non-smokers.
  • Half of the participants received 500 mg daily of sustained-release vitamin C.

Related Experiment Videos

  • Ascorbic acid levels were measured in urine and follicular fluid; IVF parameters and pregnancy rates were assessed.

    • Main Results:

    • Follicular fluid ascorbic acid levels were significantly higher in the vitamin C supplemented group (p < 0.001).
    • Vitamin C supplementation showed a statistically insignificant increase in overall pregnancy rates (34.2% vs. 23.7%).
    • Pregnancy rates were significantly higher in non-smokers (44.7%) compared to smokers (13.2%), with vitamin C showing a greater benefit in non-smokers (57.9% vs. 31.6%).

    Conclusions:

    • Vitamin C supplementation effectively increases ascorbic acid concentrations in follicular fluid during IVF.
    • While not significantly improving overall pregnancy rates, supplementation may benefit specific patient groups like non-smokers.
    • The significantly lower pregnancy rate in smokers underscores the importance of smoking cessation prior to infertility treatment.