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[Current status of reduced-intensity stem cell transplantation; survey in the Kinki area]
Takashi Ashida1, Yasuhiro Maeda, Akihisa Kanamaru
1Division of Hematology, Nephrology and Rheumatology, Department of Internal Medicine, Kinki University School of Medicine.
Abstract:
The status of reduced-intensity stem cell transplantation (RIST) in the Kinki area was investigated by questionnaires. We sent out questionnaires to 72 institutions and received 51 replies (72.2%). RIST was performed in 16 institutions (31.4%). A total of 91 cases were included of whom approximately 70% were non-remission or advanced hematological malignancies. Various conditioning regimens were used for RIST, most often consisting of fludarabine, busulfan and antithymocte globulin. Acute GVHD developed in 57% of all patients. Relapse or disease progression developed in 42.7% of evaluable patients. The overall survival rate was 54.6%, and 80% of low risk patients were alive at the time of analysis.