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Updated: Aug 8, 2026

Assessment of Resistance to Tyrosine Kinase Inhibitors by an Interrogation of Signal Transduction Pathways by Antibody Arrays
07:42

Assessment of Resistance to Tyrosine Kinase Inhibitors by an Interrogation of Signal Transduction Pathways by Antibody Arrays

Published on: September 19, 2018

Epidermal growth factor receptor family tyrosine kinases as signal integrators and therapeutic targets

Christopher J Barnes1, Rakesh Kumar

  • 1Department of Molecular and Cellular Oncology, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Blvd., Houston, TX 77030, USA.

Cancer Metastasis Reviews
|July 30, 2003
PubMed

Insights

Activating mutations in human epidermal growth factor receptor (HER) family kinases drive cancer. Targeting HER signaling pathways is a promising strategy for managing human malignancies and cancer therapy.

Area of Science:

  • Oncology
  • Molecular Biology
  • Signal Transduction

Background:

  • Activating mutations, gene amplification, and overexpression of human epidermal growth factor receptor (HER) family kinases are key drivers in various cancers.
  • HER family receptors transmit signals from their ligands and other signaling pathways.
  • HER family signaling plays an integral role in malignant transformation.

Purpose of the Study:

  • To provide an update on recent findings in HER family biology.
  • To highlight the role of HER receptors in cancer development.
  • To discuss HER receptors as targets for cancer therapy.

Main Methods:

  • Literature review of recent reports on HER family biology.
  • Analysis of the role of HER receptors in cancer.
  • Examination of HER receptors as therapeutic targets.

Main Results:

  • HER family signaling is implicated in diverse cancers.
  • HER receptors integrate signals from multiple pathways.
  • Attenuation of HER signaling is an emerging cancer management strategy.

Conclusions:

  • HER family receptors are crucial in cancer pathogenesis.
  • Targeting HER family signaling offers a viable therapeutic approach.
  • Ongoing clinical trials are evaluating strategies to attenuate HER signaling.

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