Related Experiment Video

Updated: Sep 20, 2026

Mouse Footpad Inoculation Model to Study Viral-Induced Neuroinflammatory Responses
09:07

Mouse Footpad Inoculation Model to Study Viral-Induced Neuroinflammatory Responses

Published on: June 14, 2020

Canine distemper, a re-emerging morbillivirus with complex neuropathogenic mechanisms

Christian Griot1, Marc Vandevelde, Martina Schobesberger

  • 1Institute of Virology and Immunoprophylaxis, Swiss Federal Veterinary Office, 3147 Mittelhäusern, Switzerland. Christian.Griot@ivi.admin.ch

Animal Health Research Reviews
|July 30, 2003
PubMed

Insights

Paramyxoviruses cause various diseases and neurological symptoms. Studying canine distemper virus (CDV) neuropathogenesis offers insights into preventing infections from newly discovered viruses like Hendra and Nipah.

Area of Science:

  • Veterinary Virology
  • Neurovirology
  • Infectious Diseases

Background:

  • Paramyxoviruses cause significant human and animal diseases.
  • Neurological symptoms are a common characteristic of many paramyxovirus infections.
  • Emerging viruses like Hendra and Nipah viruses share pathogenic patterns with known paramyxoviruses.

Purpose of the Study:

  • To investigate the neuropathogenesis of canine distemper virus (CDV).
  • To gain insights into the disease mechanisms of paramyxoviruses.
  • To inform prevention strategies for emerging paramyxovirus infections.

Main Methods:

  • Utilizing canine distemper virus (CDV) as a model organism.
  • Examining the neuropathological effects of CDV infection.
  • Analyzing disease progression and host response.

Main Results:

  • Canine distemper virus (CDV) infection leads to distinct neurological manifestations.
  • Specific viral mechanisms contribute to the observed neuropathogenesis.
  • Understanding CDV can elucidate broader paramyxovirus disease processes.

Conclusions:

  • Canine distemper virus (CDV) serves as a valuable model for studying paramyxovirus neuropathogenesis.
  • Insights from CDV research can aid in developing interventions for related viral diseases.
  • Further study is warranted to fully understand and prevent paramyxovirus-induced neurological conditions.

More Related Videos

A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease04:23

A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease

Published on: April 28, 2019

Isolation of Brain-infiltrating Leukocytes06:44

Isolation of Brain-infiltrating Leukocytes

Published on: June 13, 2011

Related Concept Videos

Rabies01:28

Rabies

Rabies is a lethal zoonotic disease caused by a single-stranded, negative-sense RNA virus of the Lyssavirus genus, within the family Rhabdoviridae. Its primary mode of transmission to humans is through bites or saliva-contaminated scratches from infected mammals such as dogs, bats, raccoons, or foxes. Transmission can also occur if infectious saliva contacts abraded skin or intact mucous membranes, including the conjunctiva.Viral Entry and Early ReplicationOnce introduced at the bite or scratch...
Encephalitis ll: Pathophysiology01:26

Encephalitis ll: Pathophysiology

Encephalitis is inflammation of the brain parenchyma caused by direct viral invasion or immune-mediated mechanisms triggered by infections or tumors. Both processes lead to neuronal injury, disrupted neurotransmission, and diverse neurological symptoms, often with overlapping clinical and pathological features.Autoimmune EncephalitisIn autoimmune encephalitis, antibodies target neuronal antigens on cell surfaces, synapses, or within neurons. A key example is anti-NMDAR encephalitis, which can...
Arboviral Encephalitis01:25

Arboviral Encephalitis

Arboviral encephalitis refers to brain inflammation caused by arthropod-borne viruses, particularly those transmitted through mosquito vectors. Among these, West Nile virus (WNV), a member of the Flaviviridae family, is a significant public health concern. WNV is an enveloped, positive-sense, single-stranded RNA virus. Human infection typically begins when an infected mosquito introduces the virus into the dermis during feeding. The primary transmission cycle involves birds as amplifying hosts...
Viral Recombination00:57

Viral Recombination

Cells are sometimes infected by more than one virus at once. When two viruses disassemble to expose their genomes for replication in the same cell, similar regions of their genomes can pair together and exchange sequences in a process called recombination. Alternatively, viruses with segmented genomes can swap segments in a process called reassortment.
Poliomyelitis01:17

Poliomyelitis

Poliomyelitis is caused by poliovirus, a small, non-enveloped, positive-sense RNA virus of the Picornaviridae family and Enterovirus genus. Transmission occurs primarily via the fecal-oral route, often through ingestion of contaminated water or food. The virus initially replicates in the oropharynx and intestinal mucosa, particularly in lymphoid tissues such as the tonsils, Peyer’s patches, and regional lymph nodes. Primary viremia follows, allowing dissemination throughout the body.In most...
Encephalitis l: Introduction01:19

Encephalitis l: Introduction

Encephalitis is inflammation of the brain parenchyma, most often due to infections or autoimmune processes. It presents with neuropsychiatric features such as fever, altered mental status, behavioral changes, cognitive dysfunction, seizures, focal deficits, and sometimes autonomic instability. In some cases, the meninges are also involved, resulting in meningoencephalitis.Infectious CausesInfectious encephalitis is most commonly viral but can also result from bacterial, fungal, or parasitic...