Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Electrical activity in endocrine pituitary cells in situ: a support for a multiple-function coding.

Xavier Bonnefont1, Patrice Mollard

  • 1INSERM U469, Centre CNRS-INSERM de Pharmacologie Endocrinologie, 34094 Montpellier Cedex 5, France.

FEBS Letters
|July 30, 2003
PubMed
Summary

Researchers discovered novel small-amplitude voltage fluctuations controlling spike firing in anterior pituitary endocrine cells. This finding reveals a new cellular mechanism for regulating hormone secretion and body functions.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Gonadotrophs have a dual origin, with most derived from early postnatal pituitary stem cells.

Nature communications·2025
Same author

The satiety hormone cholecystokinin gates reproduction in fish by controlling gonadotropin secretion.

eLife·2024
Same author

Protocol for in vivo recording of neural activity in deep structures of mice brain via gradient lenses by calcium imaging.

STAR protocols·2024
Same author

Paracrine FGF1 signaling directs pituitary architecture and size.

Proceedings of the National Academy of Sciences of the United States of America·2024
Same author

Prolactin blood concentration relies on the scalability of the TIDA neurons' network efficiency <i>in vivo</i>.

iScience·2024
Same author

Cell Signaling in the Circadian Pacemaker: New Insights from in vivo Imaging.

Neuroendocrinology·2024

Area of Science:

  • Endocrinology
  • Neuroscience
  • Cellular Physiology

Background:

  • The anterior pituitary gland regulates essential bodily functions through endocrine cell activity.
  • Pituitary cell function relies on membrane excitability and subsequent cytosolic calcium increases.
  • Understanding the precise mechanisms controlling pituitary cell excitability is crucial for comprehending endocrine regulation.

Purpose of the Study:

  • To identify and characterize novel patterns of electrical activity in anterior pituitary endocrine cells.
  • To investigate the role of small-amplitude voltage fluctuations in controlling pituitary cell firing patterns.
  • To explore how these electrical patterns influence calcium dynamics and hormone secretion.

Main Methods:

  • In situ electrophysiological recordings from anterior pituitary endocrine cells.

Related Experiment Videos

  • Analysis of voltage fluctuations to identify distinct patterns based on duration.
  • Correlation of voltage fluctuation patterns with cellular responses to secretagogues.

    • Main Results:

    • First identification of small-amplitude voltage fluctuations governing spike firing in pituitary endocrine cells in situ.
    • Distinguished three distinct patterns of voltage fluctuations based on their durations (1-100 seconds).
    • Observed that these fluctuation patterns could be superimposed and were influenced by secretagogues.

    Conclusions:

    • Anterior pituitary endocrine cells exhibit a unique 'cell code' involving small-amplitude voltage fluctuations.
    • This code leads to a multimodal arrangement of spike firing, offering fine-tuning of calcium-dependent cellular functions.
    • The discovered mechanism provides new insights into the regulation of hormone release and basic body functions.