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Concomitant boost radiotherapy for muscle invasive bladder cancer
Floris J Pos1, Geertjan van Tienhoven, Maarten C C M Hulshof
1Department of Radiotherapy, Academic Medical Center, University of Amsterdam, P.O. Box 22700, 1100 DE, Amsterdam, The Netherlands.
Summary
This study found that a shortened radiotherapy schedule with a partial bladder boost is feasible and effective for invasive bladder cancer. This approach offers a high chance of local control with manageable side effects.
Area of Science:
- Oncology
- Radiation Oncology
Background:
- Muscle-invasive bladder cancer requires effective radiotherapy strategies.
- Optimizing treatment time and dose delivery is crucial for improving outcomes.
Purpose of the Study:
- To assess the feasibility and efficacy of a concomitant partial bladder boost in radiotherapy for invasive bladder cancer.
- To evaluate this technique when combined with a shortened overall treatment time.
Main Methods:
- 50 patients with T2-T4 N0M0 bladder cancer received radiotherapy over 4 weeks.
- A total dose of 55 Gy was delivered in 20 fractions, with a concomitant boost to the tumor area.
- Toxicity was assessed using EORTC/RTOG criteria.
Main Results:
- The treatment was feasible with good tolerability.
- Severe acute toxicity (>/=G3) occurred in 14% of patients, and severe late toxicity in 13%.
- Complete remission was achieved in 74% of patients, with 55% 3-year freedom from local progression.
Conclusions:
- A concomitant boost technique with a shortened overall treatment time is effective for external radiotherapy in muscle-invasive bladder cancer.
- This approach provides a high probability of local control.
- The toxicity profile was deemed acceptable.