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Related Experiment Videos

Ground-glass computed tomography pattern in chronic beryllium disease: pathologic substratum and evolution.

Jean-Marc Naccache1, Sylvain Marchand-Adam, Marianne Kambouchner

  • 1Services de Pneumologie, Assistance Publique-Hôpitaux de Paris, Hôpital Avicenne, 125 rue de Stalingrad, 93009 Bobigny, France. jean-marc.naccache@wanadoo.fr

Journal of Computer Assisted Tomography
|July 30, 2003
PubMed
Summary

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This study reports on five chronic beryllium disease cases. Predominant ground-glass lung opacities on CT scans correlated with granulomas, with some cases developing cysts after corticosteroid treatment.

Area of Science:

  • Pulmonology
  • Radiology
  • Pathology

Background:

  • Chronic beryllium disease (CBD) is an interstitial lung disease.
  • Radiographic findings in CBD can be variable.
  • Ground-glass opacities on CT scans are not typically considered a predominant feature of CBD.

Observation:

  • Five cases of CBD with predominant or isolated diffuse ground-glass lung opacities on CT are presented.
  • Ground-glass attenuation patterns varied from homogeneous and isolated to patchy and predominant.
  • Histologic examination revealed florid granulomas involving alveolar-capillary walls in four cases.

Findings:

  • Diffuse ground-glass opacities on CT can be a significant manifestation of chronic beryllium disease.
  • Histopathology confirms granulomatous inflammation as the underlying pathology.

Related Experiment Videos

  • Corticosteroid therapy may lead to the development of small cysts in some CBD patients.

    • Implications:

    • CT imaging findings of ground-glass opacities should raise suspicion for CBD.
    • Early diagnosis and appropriate treatment are crucial for managing CBD.
    • Understanding the spectrum of CT findings aids in the diagnosis and management of chronic beryllium disease.