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Magnetic resonance imaging and spectroscopy in a patient with treated methylmalonic acidemia
Mayumi Takeuchi1, Masafumi Harada, Kenji Matsuzaki
1Department of Radiology, University of Tokushima, 3-18-15 Kuramoto-cho, Tokushima, Japan. mayumi@clin.med.tokushima-u.ac.jp
Abstract:
Magnetic resonance imaging (MRI) and proton magnetic resonance spectroscopy (proton MRS) findings before and after carnitine therapy in a patient with methylmalonic acidemia (MMA) are evaluated. The hyperintensity on T2-weighted image and diffusion-weighted image and the decreased apparent diffusion coefficient of bilateral basal ganglia were normalized in parallel with normalization of the elevated lactate levels and the decreased N-acetyl-aspartate levels, corresponding to improvement of clinical symptoms. MRI and proton MRS may serve as a suitable, noninvasive modality for monitoring treated MMA.