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Related Experiment Videos

Endothelial cells, tissue factor and infectious diseases.

L M Lopes-Bezerra1, S G Filler

  • 1Departamento de Biologia Celular e Genética, Instituto de Biologia Roberto Alcântara Gomes, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, RJ, Brasil. leila@uerj.br

Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Medicas E Biologicas
|July 30, 2003
PubMed
Summary

Tissue factor initiates blood clots and is crucial in homeostasis and thrombotic diseases. This review explores its role in septic shock, infectious endocarditis, and invasive aspergillosis.

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Area of Science:

  • Biochemistry
  • Immunology
  • Pathology

Background:

  • Tissue factor is a transmembrane glycoprotein activating the extrinsic coagulation pathway, vital for hemostasis and thrombosis.
  • Expressed by various cells like monocytes and platelets, its synthesis is induced by pathogens and cytokines.
  • Emerging evidence suggests tissue factor also acts as a receptor in cell signaling.

Purpose of the Study:

  • To review the role of tissue factor in the pathogenesis of specific inflammatory and infectious conditions.
  • To analyze findings from both in vivo and in vitro models concerning tissue factor's function.

Main Methods:

  • Literature review focusing on tissue factor's involvement in disease pathogenesis.
  • Analysis of in vivo and in vitro experimental data.

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Main Results:

  • Tissue factor is implicated in thrombosis during infection, sepsis, and transplant rejection.
  • Its role in septic shock, infectious endocarditis, and invasive aspergillosis is highlighted.
  • Potential cell signaling functions of tissue factor are discussed.

Conclusions:

  • Tissue factor is a key mediator in the pathogenesis of severe infections and inflammatory conditions.
  • Understanding its dual role in coagulation and cell signaling is critical for therapeutic strategies.