[Lipid peroxidation processes in epidermis of patients with psoriasis]

The evaluation of local peroxide status was studied in 42 patients with psoriasis depending on the disease stage in different age periods (from 18 to 67 years) with disease duration from 2 months to 20 years. It was established that the development of psoriatic process is accompanied with the marked changes in local peroxide status in the epidermis. It is manifested by the decrease in intensity of lipid free-and-radical oxidation. Decrease in the products of lipoperoxidation occurs in epidermis--both in the affected and intact areas in all investigated patients independently of the stage of psoriatic process. It is more expressed during the aggravation period. The minimal levels of the intermediators being studied are recorded in the psoriatic plaques.