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An In vitro Model to Study Immune Responses of Human Peripheral Blood Mononuclear Cells to Human Respiratory Syncytial Virus Infection
09:01

An In vitro Model to Study Immune Responses of Human Peripheral Blood Mononuclear Cells to Human Respiratory Syncytial Virus Infection

Published on: December 10, 2013

[Respiratory syncytial virus infections in children in general practice]

Lisa Monica Nielsen1, Jørgen Halgrener, Bjarne V Lühr Hansen

  • 1Syddansk Universitet, Forskningsenheden for Almen Medicin.

Ugeskrift for Laeger
|July 31, 2003
PubMed

Insights

Respiratory syncytial virus (RSV) is common in young children presenting with acute respiratory infections in general practice. While RSV infections are frequent, they typically present with uncomplicated clinical pictures.

Area of Science:

  • Pediatrics
  • Infectious Diseases
  • General Practice

Background:

  • Respiratory syncytial virus (RSV) is a significant cause of acute respiratory infections in infants and young children.
  • Understanding the clinical course of RSV in primary care settings is crucial for effective management.

Purpose of the Study:

  • To describe the clinical course of respiratory syncytial virus (RSV) infections in children under two years of age.
  • To compare clinical findings and disease progression in RSV-positive versus RSV-negative children.

Main Methods:

  • A prospective study involving 221 children under two years with acute respiratory infection across 59 general practices.
  • Data collection included GP registration charts, parental questionnaires, and RSV testing.
  • Comparison of clinical signs, treatment, and disease course between RSV-positive and RSV-negative groups.

Main Results:

  • Respiratory syncytial virus (RSV) was detected in 25.8% (57/221) of the children studied.
  • RSV-positive children showed a significantly higher incidence of audible wheezing upon auscultation.
  • No significant differences were observed in other clinical parameters, GP assessments, treatment choices, or disease course based on RSV status.

Conclusions:

  • Respiratory syncytial virus (RSV) infections are frequent among young children presenting with acute respiratory illness in general practice.
  • The clinical presentation of RSV infections in this age group is typically uncomplicated.
Abstract

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