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The ultimate chip shot: can microarray technology deliver for neuroscience?
1Neuroscience Research Division, Lilly Research Laboratories, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN, USA. l.nisenbaum@lilly.com
Genes, Brain, and Behavior
|July 31, 2003
Summary
Microarray technology offers a high-throughput method for studying gene expression in neuroscience. This review details experimental considerations for applying these gene chips to brain and behavior research.
Area of Science:
- Neuroscience
- Molecular Biology
- Genetics
Background:
- Microarray technology (gene chips) enables high-throughput gene expression analysis.
- Neuroscience applications have lagged due to the nervous system's complexity.
- Existing research primarily focuses on cancer and yeast genetics.
Purpose of the Study:
- To review microarray technology for neuroscience research.
- To describe experimental considerations for neuroscience array studies.
- To highlight the potential of microarrays in systems neurobiology.
Main Methods:
- Overview of cDNA and oligonucleotide microarray technologies.
- Discussion of experimental design and implementation challenges in neuroscience.
- Exploration of high-throughput gene expression analysis.
Main Results:
- Microarray technology is a powerful tool for examining gene expression.
- Challenges in neuroscience include the heterogeneous and complex organization of the nervous system.
- Successful implementation requires careful planning and consideration of experimental factors.
Conclusions:
- Microarray technology provides a molecular approach to systems neurobiology.
- This technology can yield insights into developmental neurobiology.
- It offers potential for understanding neurological and psychiatric disorders.