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Updated: Aug 18, 2026

Isolation and Chemical Characterization of Lipid A from Gram-negative Bacteria
Published on: September 16, 2013
Bactericidal/permeability-increasing protein (BPI) and lipopolysaccharide-binding protein (LBP): structure, function
1Departments of Internal Medicine and Microbiology, Division of Infectious Diseases and The Inflammation Program, Roy J. and Lucille A. Carver, College of Medicine, University of Iowa, 200 Hawkins Drive, Iowa City, IA 52242, USA. jerrold-weiss@uiowa.edu
Abstract:
Lipopolysaccharide-binding protein (LBP) and bactericidal/permeability-increasing protein (BPI) are closely related endotoxin-binding proteins that function in a co-ordinated manner to facilitate an integrated host response to invading Gram-negative bacteria. Differences in the structure and function of BPI and LBP, as well as differences in their mobilization, permit highly sensitive pro-inflammatory responses to small numbers of bacteria at the onset of bacterial invasion and, later, efficient elimination of viable bacteria and their remnants and of endotoxin-driven inflammation.
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