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Updated: Jul 19, 2026

Identifying the Effects of BRCA1 Mutations on Homologous Recombination using Cells that Express Endogenous Wild-type BRCA1
Published on: February 18, 2011
[BRCA1 protein expression in sporadic breast and its clinical significance]
Ben-zhong Wang1, Jin Wang, Qiang Wu
1Department of Surgery, First Affiliated Hospital, Anhui Medical University, Hefei 230022, China.
Objective:
To study BRCA1 gene expression in sporadic breast cancer in Han nationality and its relations to clinical pathological parameters.
Methods:
Immunohistochemical method was used to detect the BRCA1 protein in paraffin embedded breast cancer tissue of 51 patients. The relationship between BRCA1 protein and clinical pathological features was analysed.
Results:
BRCA1 protein was located in the nuclear of breast cancer cells. The rate of its down regulation of expression was 49.0% (25/51), which correlated reversely with c-erbB-2 protein, but did not correlate with histological grading, tumor size, lymph node involvement and patient age.
Conclusion:
The detection of BRCA1 protein expression may be a reflection of its gene alteration. So it may be a primary method for screening the susceptibility to breast cancer.
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