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Human Liver Microphysiological System for Assessing Drug-Induced Liver Toxicity In Vitro
11:06

Human Liver Microphysiological System for Assessing Drug-Induced Liver Toxicity In Vitro

Published on: January 31, 2022

[Liver failure due to mushroom poisoning: clinical course and new treatment perspectives]

M V Catalina1, O Núñez, A Ponferrada

  • 1Servicio de Aparato Digestivo. Sección de Hepatología. Hospital General Universitario Gregorio Marañón. Madrid. España.

Gastroenterologia Y Hepatologia
|July 31, 2003
PubMed

Insights

Mushroom poisoning, primarily from Amanita species, is a rare but serious medical emergency. Early treatment and advanced therapies like MARS can improve outcomes for severe liver failure.

Area of Science:

  • Toxicology
  • Hepatology
  • Emergency Medicine

Background:

  • Mushroom poisoning, particularly from Amanita species, is an infrequent cause of liver failure.
  • It presents a high morbidity and mortality, constituting a medical emergency.

Observation:

  • Initial symptoms like vomiting and abdominal pain are nonspecific and can mimic gastroenteritis.
  • Severe cases can progress to renal and hepatic failure, necessitating interventions such as liver transplantation or albumin dialysis.

Findings:

  • Three cases demonstrated varied clinical courses, from full recovery with conventional treatment to acute liver failure.
  • Penicillin G and silymarin showed potential utility in treatment.
  • Extracorporeal detoxification, specifically molecular absorbent recycling system (MARS) dialysis, offered a favorable outcome in severe cases.

Implications:

  • Prompt diagnosis and intervention are crucial for managing mushroom poisoning.
  • MARS dialysis represents a significant supportive treatment option for patients with severe liver dysfunction due to mushroom toxicity.
  • Further research into standardized treatment protocols for mushroom poisoning is warranted.

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