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Cell polarity: the ups and downs of the Par6/aPKC complex
Domingos Henrique1, François Schweisguth
1Instituto Medicina Molecular, Faculdade de Medicina de Lisboa, Av. Prof. Egas Moniz, 1649-028, Lisboa, Portugal. henrique@fm.ul.pt
Current Opinion in Genetics & Development
|July 31, 2003
Abstract:
A signaling complex in which atypical protein kinase C associates with a regulatory protein, Par6, plays an essential role in establishing cell polarity. Recent studies in organisms ranging from worms to mammals have highlighted some of the conserved mechanisms by which the assembly, localization and activity of this complex are regulated. Recent work is also beginning to unravel how this complex acts in concert with additional molecular complexes to establish and maintain polarity.