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Related Experiment Videos

Bioengineered corneas: how close are we?

David J Carlsson1, Fengfu Li, Shigeto Shimmura

  • 1National Research Council (ICPET) Canada, Ottawa, Ontario, Canada.

Current Opinion in Ophthalmology
|July 31, 2003
PubMed
Summary

Bioengineered corneas offer alternatives to human donor tissue for treating corneal damage. Innovations include regenerative hydrogels, prosthetic devices, and synthetic onlays for vision correction.

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Area of Science:

  • Ophthalmology and Regenerative Medicine
  • Biomaterials Science and Engineering

Background:

  • Human donor corneas are limited in supply for transplantation.
  • Damaged or diseased corneas necessitate functional or regenerative replacements.
  • Existing treatments for refractive errors have limitations.

Purpose of the Study:

  • To review recent advancements in bioengineered corneas.
  • To explore diverse applications from functional replacement to vision correction.
  • To highlight emerging technologies in corneal tissue engineering.

Main Methods:

  • Analysis of clinical trials for artificial corneas (prostheses).
  • Development of tissue-engineered hydrogels for host tissue regeneration.
  • Creation of bioengineered lenticules for refractive correction.

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  • Investigation of biosynthetic matrices for corneal repair.
  • Evaluation of synthetic corneal onlays for refractive error correction.

    • Main Results:

    • Successful clinical trials of prosthetic artificial corneas.
    • Development of natural corneal replacements and regenerative biosynthetic matrices.
    • Promising results for synthetic corneal onlays in correcting refractive errors.
    • Bioengineered lenticules show potential as an alternative to refractive surgery.

    Conclusions:

    • Bioengineered corneas represent a significant advancement in ophthalmology.
    • These innovations offer solutions for both corneal disease and refractive errors.
    • Future developments focus on regeneration and improved visual outcomes.