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Related Experiment Videos

Type II transmembrane serine proteases.

Roman Szabo1, Qingyu Wu, Robert B Dickson

  • 1Oral and Pharyngeal Cancer Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA.

Thrombosis and Haemostasis
|July 31, 2003
PubMed
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Genome sequencing revealed a new family of type II transmembrane serine proteases (TTSPs). These proteases play critical roles in development and health, and their abnormal expression may link to disease progression.

Area of Science:

  • Genomics
  • Protease biology
  • Molecular genetics

Background:

  • The advent of human and mouse genome sequences and EST databases enabled the discovery of novel protein families.
  • Membrane-anchored serine proteases, specifically type II transmembrane serine proteases (TTSPs), represent a significant new class of enzymes.
  • Emerging evidence suggests TTSPs are involved in crucial biological processes.

Purpose of the Study:

  • To review the current knowledge on the genetics, physiology, and pathology of the type II transmembrane serine protease (TTSP) family.
  • To highlight the significance of TTSPs in human development and health.
  • To discuss the potential role of TTSPs in disease pathogenesis.

Main Methods:

  • Bioinformatic analysis of genome and expressed sequence tag databases.

Related Experiment Videos

  • Review of studies on human inherited disorders.
  • Analysis of gene targeting experiments in mouse models.

    • Main Results:

    • Identification of a large family of type II transmembrane serine proteases (TTSPs).
    • Demonstration of critical roles for several TTSPs in development and health through genetic studies.
    • Preliminary findings linking aberrant TTSP expression to disease progression.

    Conclusions:

    • Type II transmembrane serine proteases (TTSPs) are a newly identified, important family of enzymes.
    • TTSPs possess critical physiological functions, impacting development and overall health.
    • Dysregulation of TTSPs presents a potential avenue for disease development and progression, warranting further investigation.