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Updated: Aug 19, 2026

Absorption of Nasal and Bronchial Fluids: Precision Sampling of the Human Respiratory Mucosa and Laboratory Processing of Samples
Published on: January 21, 2018
[Expression of chloride channel in nasal mucosa with allergic rhinitis]
Hua-bin Li1, De-min Han, Bing Zhou
1Beijing Institute of Otolaryngology, Department of Otolaryngology Head and Neck Surgery, Tongren Hospital, Capital Medical University, Beijing, 100005, China. lhb7351@hotmail.com
Objective:
To evaluate the role of chloride channel ClC-3 in perennial allergic rhinitis.
Methods:
The nasal mucosa from 19 patients with perennial allergic rhinitis were studied by immunohistochemistric staining and reverse transcriptase polymerase chain reaction (RT-PCR) for the expression of ClC-3.
Results:
ClC-3 was positively stained in 17 cases of 19 patients, with a rate of 89.6%. It mainly distributed in cytoplasm of epithelium and submucosal gland. All tissues displayed expected DNA length after PCR. The relative density of ClC-3 in mucosa with allergic rhinitis was 0.685 +/- 0.114 and 0.140 +/- 0.075 in normal.
Conclusion:
ClC-3 played an important role in the over-secretion of liquor in allergic rhinitis.
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