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Studies on antidiabetic effects of cortex Moutan polysaccharide-2b in type 2 diabetes mellitus rats
Hao Hong1, Qin-mao Wang, Zhi-ping Zhao
1Department of Pharmacology, China Pharmaceutical University, Nanjing 210009, China.
Aim:
To study the antidiabetic effects of cortex Moutan polysaccharide-2b (CMP-2b) in type 2 diabetes mellitus (T2DM) rats.
Methods:
The T2DM model rats were induced by a single intravenous injection of low dose streptozotocin (STZ) and intake of high sucrose-fat diet. CMP-2b was given to T2DM rats daily through gavage for 4-5 weeks. The body weight, water and food intake, fasting blood glucose (FBG), glucose tolerance, plasma lipids, serum insulin, and insulin receptor (Ins R) were determined.
Results:
Oral administration of CMP-2b significantly decreased water and food intake, FBG, total cholesterol (Tch), and triglyceride (TG), improved the impaired glucose tolerance (IGT), and remarkably raised the number of low affinity InsR and insulin sensitivity index (ISI) in T2DM rats.
Conclusion:
CMP-2b may be useful for treating T2DM and its complications.
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