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Updated: Aug 9, 2026

Investigating Functional Regeneration in Organotypic Spinal Cord Co-cultures Grown on Multi-electrode Arrays
Published on: September 23, 2015
[Evolutionary aspects of compensation of functions of the damaged spinal cord]
1Orbeli Institute of Physiology, National Academy of Sciences of Armenia, Yerevan, Armenia.
Abstract:
In animal experiments with spinal lesions, phylo- and ontogenetic features of development of plasticity in the CNS of mammals and high reliability of the CNS have been demonstrated. It has been shown that possibilities of compensation processes and the upper limit of plasticity increase in phylogeny. Much attention has been attached to the higher regions of the CNS and hypothalamus as well as to ecological and biological characteristics of animals. Changes in the structure and functions of the damaged spinal cord have been studied. The significance of sympathetic innervation and involvement of ATP and ATPase in the spinal cord functioning after injury have been demonstrated. The article reviews the investigations of the role of the cicatrixce and some endocrine glands (adrenal glands, pancreas, and thyroid gland) performed at the laboratory. In phylogeny, high plasticity has been demonstrated at early ontogenetic stages. Enzymes have been shown to facilitate recovery of spinal functions after injury.
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