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Application of a two-stage temperature control strategy for enhanced glutathione production in the batch fermentation
Gongyuan Wei1, Yin Li, Guocheng Du
1Key Laboratory of Industrial Biotechnology, Ministry of Education, Southern Yangtze University, Wuxi 214036, P.R. China.
Biotechnology Letters
|August 2, 2003
Abstract:
In batch culture for glutathione production with Candida utilis, a higher temperature (30 degrees C) was required to hasten cell growth while a lower temperature (26 degrees C) was needed to increase the production of glutathione. A two-stage temperature control strategy was used to enhance both the yield and the productivity of glutathione. As a result, glutathione production was increased by 5% and 23% of that at 26 degrees C and 30 degrees C, respectively, and the intracellular glutathione content reached 2.5% (w/w).