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Related Concept Videos

Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

4.8K
Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
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Stem Cell Culture01:17

Stem Cell Culture

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Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
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Embryonic Stem Cells00:58

Embryonic Stem Cells

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Embryonic stem (ES) cells are undifferentiated pluripotent cells, meaning they can produce any cell type in the body. This gives them tremendous potential in science and medicine since they can generate specific cell types for use in research or to replace body cells lost due to damage or disease.
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Embryonic Stem Cells00:57

Embryonic Stem Cells

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Embryonic stem (ES) cells were first discovered in mice in 1981 by Martin Evans. In 1998, James Thomson identified a method to isolate embryonic stem cells from humans. Human embryonic stem cells (hESCs) are obtained from 3-5 day old embryos that remain unused after an in vitro fertilization procedure.
ES cells are grown in a culture medium where they can divide indefinitely, creating ES cell lines. Under certain conditions, ES cells can differentiate, either spontaneously into a variety of...
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iPS Cell Differentiation01:22

iPS Cell Differentiation

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The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.
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Mesenchymal Stem Cells01:19

Mesenchymal Stem Cells

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Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their...
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Phase II study of tacrolimus and methotrexate for prophylaxis of acute graft-versus-host disease after HLA-A, B, and DRB1 genotypically mismatched unrelated bone marrow transplantation among Japanese patients.

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Related Experiment Video

Updated: Mar 24, 2026

Evaluation of Stem Cell Therapies in a Bilateral Patellar Tendon Injury Model in Rats
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Evaluation of Stem Cell Therapies in a Bilateral Patellar Tendon Injury Model in Rats

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Stem cells and regenerative medicine.

Hisamaru Hirai1

  • 1Department of Hematology & Oncology, Graduate School of Medicine, University of Tokyo, Hongo, Japan.

Human Cell
|August 2, 2003
PubMed
Summary

Stem cell research has advanced developmental biology understanding and offers hope for regenerative medicine. Scientists are exploring stem cell plasticity and therapies for clinical application.

Area of Science:

  • * Developmental Biology
  • * Regenerative Medicine
  • * Stem Cell Biology

Background:

  • * Stem cells are clonogenic cells capable of self-renewal and differentiation.
  • * Stem cells are found in various adult tissues, with potential to form multiple cell types.
  • * Human embryonic stem cell lines have enabled generation of diverse human tissues.

Purpose of the Study:

  • * To review the contributions of stem cell research to developmental biology.
  • * To explore the potential of stem cell therapies for treating diseases.
  • * To discuss recent findings on adult stem cell plasticity and multipotent somatic stem cells.

Main Methods:

  • * Review of scientific literature on stem cell biology and applications.
  • * Analysis of research findings on stem cell differentiation and plasticity.

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Isolation of Perivascular Multipotent Precursor Cell Populations from Human Cardiac Tissue

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Isolating Stem Cells from Soft Musculoskeletal Tissues

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Last Updated: Mar 24, 2026

Evaluation of Stem Cell Therapies in a Bilateral Patellar Tendon Injury Model in Rats
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Isolation of Perivascular Multipotent Precursor Cell Populations from Human Cardiac Tissue
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Isolation of Perivascular Multipotent Precursor Cell Populations from Human Cardiac Tissue

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  • * Examination of advancements in stem cell technologies for clinical translation.

    • Main Results:

    • * Stem cell research has significantly enhanced understanding of developmental processes.
    • * Stem cells hold promise for cell replacement therapies for various diseases.
    • * Evidence suggests adult stem cells possess greater developmental plasticity than previously thought, including multipotent somatic stem cells in bone marrow.

    Conclusions:

    • * Stem cell research has made significant contributions to developmental biology and regenerative medicine.
    • * The plasticity of adult stem cells is an active area of research with therapeutic implications.
    • * Ongoing research and technological advancements are paving the way for clinical stem cell therapies.