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Granular lymphocyte proliferative disorder after autologous peripheral blood stem cell transplantation for multiple

K Kawakubo1, T Endo, K Koizumi

  • 1Department of Internal Medicine II, Hokkaido University School of Medicine, Sapporo, Japan.

European Journal of Haematology
|August 2, 2003
PubMed

A 57-yr-old woman with multiple myeloma underwent tandem autologous peripheral blood stem cell transplantation (APBSCT). Fever, anemia, and thrombocytopenia, followed by the proliferation of granular lymphocytes in the peripheral blood occurred, after a second APBSCT. Clonal rearrangement of the T-cell receptor was detected using Southern blot analysis of peripheral blood samples. Granular lymphocyte proliferative disorders (GLPD) were diagnosed. After steroid therapy, the symptoms resolved. Lymphocytosis did not recur after the discontinuation of steroids. There have been a few reports of GLPD after solid organ and allogeneic hematopoietic stem cell transplantations. We report a first case of GLPD after APBSCT.

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