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Related Experiment Videos

An evaluation of dermoscopy fluids and application techniques.

A J Gewirtzman1, J-H Saurat, R P Braun

  • 1Pigmented Skin Lesion Clinic, Department of Dermatology, University Hospital Geneva, 24, rue Micheli-du-Crest, CH-1211 Geneva 14, Switzerland.

The British Journal of Dermatology
|August 2, 2003
PubMed
Summary

The best immersion fluid for dermoscopy is 70% ethanol, offering clear images with minimal air bubbles. This fluid is preferred for its odorless, non-staining, and quick-evaporating properties, though ultrasound gel is useful for specific applications.

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Area of Science:

  • Dermatology
  • Medical Imaging
  • Optical Physics

Background:

  • Dermoscopy is a widely adopted, non-invasive method for visualizing skin lesions.
  • Optimal immersion fluid (IF) selection and application techniques for dermoscopy remain under-investigated.

Purpose of the Study:

  • To identify optimal IF application techniques for dermoscopy.
  • To determine which IFs minimize air inclusions.
  • To assess IFs for best diagnostic image quality.

Main Methods:

  • A three-phase study evaluated IF application techniques, quantified air inclusions across seven IFs, and judged image clarity.
  • Digital dermoscopic photography techniques were optimized to exclude air bubbles.
  • Quantitative and qualitative assessments of IF performance were conducted.

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Main Results:

  • The 'roll-on technique' with an eyedropper application of IF is most effective at minimizing air bubbles.
  • Alcoholic IFs (70% ethanol, 90% isopropanol) yielded fewer air inclusions compared to mineral oil.
  • Image clarity was comparable between alcoholic IFs and mineral oil, while ultrasound gel and water produced slightly blurred images.

Conclusions:

  • 70% ethanol is recommended as the preferred IF due to its favorable properties, including being odorless, non-staining, and self-evaporating.
  • 90% isopropanol shows slightly fewer air inclusions but is less preferred due to odor.
  • Ultrasound gel is a suitable alternative for specific applications like mucosal or nail dermoscopy where fluid containment is crucial.