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Updated: Aug 14, 2026
CUBIC Protocol Visualizes Protein Expression at Single Cell Resolution in Whole Mount Skin Preparations
Published on: August 4, 2016
Trichilemmoma: an immunohistochemical study of cytokeratins
I Kurokawa1, S Nishijima, K Kusumoto
1Department of Dermatology, Hyogo Prefectural Tsukaguchi Hospital, 6-8-17, Minamitsukaguchi-cho, Amagasaki, Hyogo 661-0012, Japan. ikuro@aa.alles.or.jp
Background:
The histogenesis of trichilemmoma remains unclear.
Objectives:
To clarify the histogenesis of trichilemmoma by evaluating its cytokeratin (CK) expression.
Methods:
In three cases of trichilemmoma, CK expression was studied immunohistochemically using seven antikeratin antibodies against CK1, 10, 14-17 and 19, respectively.
Results:
CK1 and CK10 were present in keratinizing ductal epithelium. CK14 was present in the whole layer. CK15 was present in suprabasal layers in two cases. CK16 was present in the suprabasal layer, but was absent in keratinizing ductal epithelium. CK17 was present in suprabasal layers and the sebaceous duct-like structure. CK19 was totally absent.
Conclusions:
These results showed that trichilemmoma may differentiate mainly towards two directions: infundibular keratinization and proliferation of the outer root sheath with undifferentiated and pluripotent characteristics.
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