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Related Experiment Videos

Circulating natural killer cells in psoriasis.

A L Cameron1, B Kirby, C E M Griffiths

  • 1Dermatopharmacology Unit, The Dermatology Centre, University of Manchester, Hope Hospital, Salford, Manchester M6 8HD, U.K.

The British Journal of Dermatology
|August 2, 2003
PubMed
Summary
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Patients with psoriasis have significantly fewer natural killer (NK) cells in their peripheral blood compared to healthy individuals. This finding suggests NK cells may play a role in psoriasis, potentially indicating it

Area of Science:

  • Immunology
  • Dermatology
  • Autoimmune Diseases

Background:

  • Psoriasis is an immune-mediated disease involving T-helper type 1 cytokines.
  • Established autoimmune diseases like rheumatoid arthritis share mechanistic similarities with psoriasis.
  • Natural killer (NK) and NK-T cells are implicated in pathogenesis of autoimmune conditions, often with reduced peripheral blood NK cell counts.

Purpose of the Study:

  • To investigate potential reductions in circulating NK and NK-T cells in psoriasis patients.
  • To compare peripheral blood levels of NK and NK-T cells between psoriasis patients and healthy controls.

Main Methods:

  • Analyzed peripheral blood mononuclear cells from 14 untreated psoriasis patients and 13 healthy controls.
  • Utilized triple-color flow cytometry with antibodies targeting NK cell markers (CD16, CD56, CD94, CD158a) and T-cell/activation markers (CD3, CD57, CD69, CLA).

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  • Compared cell counts between patient and control groups.

    • Main Results:

    • Significantly lower counts of NK cells expressing CD16, CD56, CD94, and CD158a were observed in psoriasis patients (P < 0.001 to P < 0.02).
    • No significant differences were found in circulating NK-T cells, T-cells, activated lymphocytes, or CLA+ cells between groups.
    • Peripheral blood NK cell numbers are demonstrably reduced in individuals with psoriasis.

    Conclusions:

    • Circulating NK cells are significantly reduced in patients with psoriasis.
    • This reduction mirrors findings in established autoimmune diseases, supporting a potential autoimmune basis for psoriasis.
    • NK cells may play a crucial role in the pathogenesis of psoriasis.