Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Neuroendocrine profiles in mood disorders.

Paul Linkowski1

  • 1Sleep Laboratory, Department of Psychiatry, Hpital Erasme, Universit Libre de Bruxelles, Belgium. Paul.Linkowski@ulb.ac.be

The International Journal of Neuropsychopharmacology
|August 2, 2003
PubMed
Summary

Major depression is linked to disrupted circadian rhythms affecting cortisol and growth hormone secretion. Treatment normalizes these neuroendocrine and sleep abnormalities, suggesting a state-dependent condition.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Using Bayesian Networks to Investigate Psychological Constructs: The Case of Empathy.

Psychological reports·2022
Same author

A network structure of manic symptoms.

Brain and behavior·2021
Same author

Bayesian Network Structure and Predictability of Autistic Traits.

Psychological reports·2020
Same author

A Machine Learning Approach to Relationships Among Alexithymia Components.

Psychiatria Danubina·2020
Same author

Network Structures of Symptoms From the Zung Depression Scale.

Psychological reports·2020
Same author

Alterations of neural network organization during REM sleep in women: implication for sex differences in vulnerability to mood disorders.

Biology of sex differences·2020

Area of Science:

  • Neuroendocrinology
  • Chronobiology
  • Psychiatry

Background:

  • Neuroendocrine abnormalities are increasingly studied in major mental illnesses like depression.
  • Neuroendocrine challenge tests show potential as biological markers for mental disorders.
  • Modern approaches examine circadian and pulsatile hormonal profiles to understand physiological modulation.

Purpose of the Study:

  • To investigate the hypothesis that circadian rhythm abnormalities are present in affective illness.
  • To clarify the control and significance of temporal sleep and wake fluctuations in neuroendocrine activity.
  • To analyze hormonal dynamics in depressed patients using frequent sampling over 24 hours.

Main Methods:

  • Chronobiological studies involving frequent sampling over a 24-hour cycle.
  • Simultaneous sleep recordings in depressed patients.
  • Assessment of neuroendocrine profiles, including cortisol, growth hormone, and prolactin.

Main Results:

  • Depressed patients exhibit 24-hour cortisol hypersecretion and diurnal growth hormone hypersecretion.
  • Normal 24-hour prolactin levels were observed in depressed patients.
  • Successful antidepressant treatment corrected most neuroendocrine and sleep abnormalities, including REM latency.

Conclusions:

  • Disordered circadian time-keeping characterizes acute episodes of major endogenous depression in some patients.
  • Abnormalities in adrenocorticotropic and somatotropic activities appear to be state-dependent.
  • Normalization of hormonal secretion timing correlates with improved sleep patterns and reduced depressive symptoms.

Related Experiment Videos