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Global screening for human viral pathogens.

Norman G Anderson1, John L Gerin, N Leigh Anderson

  • 1Viral Defense Foundation, Kensington, Maryland 20891, USA. Nornananderson@viraldefense.org

Emerging Infectious Diseases
|August 2, 2003
PubMed
Summary
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We propose a novel system for continuous surveillance of human viral pathogens using physical isolation and shotgun sequencing of viruses from pooled serum and plasma samples. This approach enables monitoring known viruses, detecting outbreaks, and discovering new viral threats.

Area of Science:

  • Virology
  • Genomics
  • Public Health Surveillance

Background:

  • Ongoing surveillance of viral pathogens in large human populations is crucial for public health.
  • Existing technologies for virion concentration and viral mixture sequencing offer a foundation for a human virome surveillance system.

Purpose of the Study:

  • To propose an integrated, automated, and contained system for continuous surveillance of viral pathogens in human populations.
  • To leverage existing technologies for concentrating, purifying, and sequencing viral genomes from large sample volumes.

Main Methods:

  • Physical isolation of viruses from large pooled human serum and plasma samples.
  • Shotgun sequencing of the isolated viral genomes.
  • Integration of existing concentration and sequencing technologies from virology and marine science.

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Main Results:

  • The proposed system can be implemented within 1-2 years, integrating established and recently developed technologies.
  • The system enables monitoring of known viruses and rapid detection of outbreaks.
  • The system facilitates the systematic discovery of novel or variant human viruses.

Conclusions:

  • An automated and contained system for human virome surveillance is feasible.
  • This system will enhance our ability to track and respond to viral threats.
  • Continuous surveillance will improve understanding of viral dynamics in human populations.