Related Experiment Videos
Screening for inducers of kinase degradation
1Urologic Oncology Branch, Center for Cancer Research, National Cancer Institute, 9610 Medical Center Drive, Rockville, MD 20850, USA.
Chemistry & Biology
|August 2, 2003
Abstract:
Targeted small molecule-induced protein degradation is a promising approach to inhibit signaling within kinase cascades. In this issue, researchers describe a simple assay for the rapid, high-throughput identification of novel agents that promote degradation of the kinases Her2 and EGFR.