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Updated: Aug 2, 2026

A Pleural Effusion Model in Rats by Intratracheal Instillation of Polyacrylate/Nanosilica
Published on: April 12, 2019
Positive end-expiratory pressure modulates perfluorochemical evaporation from the lungs
D Trevisanuto1, M J Jeng, C M Weis
1Department of Pediatrics, Padua University, Padua, Italy. trevo@child.pedi.unipd.it
Abstract:
To study the effects of positive end-expiratory pressure (PEEP) level on perfluorochemical (PFC) elimination profiles (E(L)), 6 ml/kg of perflubron were instilled into healthy anesthetized rabbits. The ventilation strategy was to maintain constant minute ventilation (300 ml/kg/min) and mean airway pressure (7-8 cm H(2)O) while randomly changing the PEEP levels from 5 to 0, 1, 3, and 10 cm H(2)O, each for a period of 15 min. The PFC content in the expired gas was measured and the E(L) was calculated. There was a significant reduction in the E(L) when decreasing the PEEP levels from 5 to 0 cm H(2)O, but no differences were seen when the PEEP was increased from 5 to 10 cm H(2)O. The results indicate that PEEP levels influence PFC elimination profiles; therefore, the measurement of the E(L) and PEEP levels should be considered when optimizing supplemental PFCs during partial liquid ventilation.
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