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Anticardiolipin antibodies and coronary heart disease

D A Tsakiris1, G A Marbet, F Burkart

  • 1Coagulation and Fibrinolysis Laboratory, Kantonsspital Basel, Switzerland.

European Heart Journal
|December 1, 1992
PubMed

Insights

Anticardiolipin antibodies (aCL) are not a reliable marker for predicting coronary heart disease progression or recurrent thrombotic events in patients. This study found no correlation between aCL, haemostasis markers, and cardiovascular disease outcomes.

Area of Science:

  • Cardiology
  • Immunology
  • Hematology

Background:

  • Anticardiolipin antibodies (aCL) are associated with thrombotic events.
  • Their role as a predisposing factor or prognostic marker for coronary artery disease requires investigation.

Purpose of the Study:

  • To determine if anticardiolipin antibodies (aCL) are a risk factor for coronary artery occlusions.
  • To assess if aCL can serve as a prognostic marker for coronary heart disease (CHD).

Main Methods:

  • Studied 232 patients from the European Concerted Action on Thrombosis Angina Pectoris Study.
  • Assessed aCL and haemostatic parameters at baseline.
  • Conducted 12 and 24-month follow-ups including angiography, thrombotic event assessment, and outcome evaluation.

Main Results:

  • Anticardiolipin antibodies (aCL) were not found to be a marker for progressive cardiovascular disease.
  • aCL did not predict recurrent thrombotic events.
  • No correlation was observed between high haemostasis activation markers and recurrent cardiovascular disease in either aCL-positive or aCL-negative patients.

Conclusions:

  • Anticardiolipin antibodies (aCL) do not appear to be a significant prognostic marker for coronary heart disease or recurrent thrombotic events.
  • Haemostasis activation markers do not correlate with cardiovascular disease prognosis in the presence or absence of aCL.

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