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[Lipidic profile: evolution, tendency and tracking from infancy to adulthood. PECNA Study]
F Repáraz1, R Elcarte, J Iñigo
1Servicio de Medicina Preventiva, Hospital Virgen del Camino, Pamplona.
Insights
Cardiovascular risk factors in children can be tracked from infancy to adulthood. This study shows that high cholesterol levels in youth often persist, highlighting the need for early intervention.
Area of Science:
- Pediatric cardiology
- Epidemiology of cardiovascular disease
- Public health
Context:
- Cardiovascular diseases originate in infancy but manifest in adulthood.
- The Pediatric Epidemiology of Cardiovascular Risk Factors in Navarra (PECNA) study began in 1987.
- Longitudinal analysis of infant-juvenile populations is crucial for understanding disease progression.
Purpose:
- To analyze the evolution of lipid profiles from age 4 to 23.
- To examine trends in cardiovascular risk factors from 1987 to 1993.
- To assess the prevalence of hypercholesterolemia and tracking of lipid variables from infancy to adulthood.
Summary:
- Lipid profiles and hypercholesterolemia prevalence were tracked in a Navarra cohort from 1987-1993.
- Significant sex-based differences in lipid profiles were observed.
- Average total cholesterol and hypercholesterolemia prevalence decreased, yet 50-55% of individuals in extreme lipid quintiles maintained their level six years later.
Impact:
- Highlights persistent lipid abnormalities from childhood into adulthood.
- Informs early intervention strategies for cardiovascular disease prevention.
- Provides valuable data on secular trends in pediatric lipid profiles.
Abstract:
Cardiovascular diseases start during infancy, although the clinical manifestations show themselves during adulthood. Since the year 1987 a (PECNA) study has been underway in Navarra to analyse the epidemiology of the cardiovascular risk factors of the infant-juvenile population. This paper presents the evolution of the lipidic profile from 4 to 23 years of age, the tendency from 1987 to 1993, the evolution of the prevalence of hypercholesterolaemia seric cholesterol >200 mg/dl and the tracking from infancy to adult age. Outstanding amongst the results are the differences between the lipidic profile in both sexes, as well as the observed fall in the average levels of total seric cholesterol and in the prevalence of hypercholesterolaemia. With regard to the tracking, it is concluded that between 50% and 55% of individuals belonging to the extreme quintile of the distribution of the lipidic variables persist at this level six years later.