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[Lipidic profile: evolution, tendency and tracking from infancy to adulthood. PECNA Study].

F Repáraz1, R Elcarte, J Iñigo

  • 1Servicio de Medicina Preventiva, Hospital Virgen del Camino, Pamplona.

Anales Del Sistema Sanitario De Navarra
|August 2, 2003
PubMed
Summary

Cardiovascular risk factors in children can be tracked from infancy to adulthood. This study shows that high cholesterol levels in youth often persist, highlighting the need for early intervention.

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Area of Science:

  • Pediatric cardiology
  • Epidemiology of cardiovascular disease
  • Public health

Context:

  • Cardiovascular diseases originate in infancy but manifest in adulthood.
  • The Pediatric Epidemiology of Cardiovascular Risk Factors in Navarra (PECNA) study began in 1987.
  • Longitudinal analysis of infant-juvenile populations is crucial for understanding disease progression.

Purpose:

  • To analyze the evolution of lipid profiles from age 4 to 23.
  • To examine trends in cardiovascular risk factors from 1987 to 1993.
  • To assess the prevalence of hypercholesterolemia and tracking of lipid variables from infancy to adulthood.

Summary:

  • Lipid profiles and hypercholesterolemia prevalence were tracked in a Navarra cohort from 1987-1993.
  • Significant sex-based differences in lipid profiles were observed.

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  • Average total cholesterol and hypercholesterolemia prevalence decreased, yet 50-55% of individuals in extreme lipid quintiles maintained their level six years later.

    • Impact:

    • Highlights persistent lipid abnormalities from childhood into adulthood.
    • Informs early intervention strategies for cardiovascular disease prevention.
    • Provides valuable data on secular trends in pediatric lipid profiles.