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Published on: August 22, 2012
Childhood constipation: longitudinal follow-up beyond puberty
Rijk van Ginkel1, Johannes B Reitsma, Hans A Büller
1Department of Pediatric Gastroenterology and Nutrition, Emma Children's Hospital/Academic Medical Center, Amsterdam, The Netherlands.
Insights
Childhood constipation often persists into adulthood, with 30% of patients still experiencing symptoms past puberty. Successful treatment rates reach 60% at one year but relapses are common, especially in boys.
Area of Science:
- Pediatric Gastroenterology
- Clinical Prognosis Studies
Background:
- Limited data exist on the long-term prognosis of childhood constipation.
- Understanding persistence into adulthood is crucial for effective management.
Purpose of the Study:
- To investigate the long-term outcomes and prognosis of childhood constipation.
- To assess the persistence of constipation into adulthood.
Main Methods:
- Prospective follow-up of 418 constipated children (aged >5 years) after intensive treatment.
- Data collected annually for up to 8 years using standardized questionnaires.
Main Results:
- 60% of children achieved successful treatment at 1 year, rising to 80% by 8 years.
- 30% of patients aged 16+ years still had constipation.
- Relapses occurred in 50% of successfully treated children, more frequently in boys.
Conclusions:
- Intensive initial treatment leads to successful outcomes in 60% of children within a year.
- A significant proportion (one-third) of patients experience persistent constipation beyond puberty.
- Findings challenge the belief that childhood constipation resolves spontaneously during puberty.
Background & Aims:
Sparse data exist about the prognosis of childhood constipation and its possible persistence into adulthood.
Methods:
A total of 418 constipated patients older than 5 years at intake (279 boys; median age, 8.0 yr) participated in studies evaluating therapeutic modalities for constipation. All children subsequently were enrolled in this follow-up study with prospective data collection after an initial 6-week intensive treatment protocol, at 6 months, and thereafter annually, using a standardized questionnaire.
Results:
Follow-up was obtained in more than 95% of the children. The median duration of the follow-up period was 5 years (range, 1-8 yr). The cumulative percentage of children who were treated successfully during follow-up was 60% at 1 year, increasing to 80% at 8 years. Successful treatment was more frequent in children without encopresis and in children with an age of onset of defecation difficulty older than 4 years. In the group of children treated successfully, 50% experienced at least one period of relapse. Relapses occurred more frequently in boys than in girls (relative risk 1.73; 95% confidence interval, 1.15-2.62). In the subset of children aged 16 years and older, constipation still was present in 30%.
Conclusions:
After intensive initial medical and behavioral treatment, 60% of all children referred to a tertiary medical center for chronic constipation were treated successfully at 1 year of follow-up. One third of the children followed-up beyond puberty continued to have severe complaints of constipation. This finding contradicts the general belief that childhood constipation gradually disappears before or during puberty.
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