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[Withdrawal symptoms in a neonate following exposure to venlafaxine during pregnancy]

R A de Moor1, L Mourad, J ter Haar

  • 1Afd. Kindergeneeskunde, TweeSteden ziekenhuis, Postbus 90.107, 5000 LA Tilburg. rdmoor@tsz.nl

Nederlands Tijdschrift Voor Geneeskunde
|August 2, 2003
PubMed

Withdrawal symptoms occurred in a male neonate after maternal use of venlafaxine for depression during pregnancy. The symptoms were restlessness, hypertonia, jitteriness, irritability and poor feeding. The diagnosis was confirmed by a temporary improvement after administration of a low dose (1 mg) of venlafaxine to the boy. Eventually the symptoms began to decline spontaneously, and ceased after 8 days. Exposure to venlafaxine and other antidepressants which inhibit serotonin reuptake during the third trimester of pregnancy carries the risk of a neonatal withdrawal syndrome.

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