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A Robust Pneumonia Model in Immunocompetent Rodents to Evaluate Antibacterial Efficacy against S. pneumoniae, H. influenzae, K. pneumoniae, P. aeruginosa or A. baumannii

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Weekly oral vitamin K prophylaxis in Denmark.

K N Hansen¹, M Minousis, F Ebbesen

¹Department of Paediatrics, Viborg-Kjellerup Hospital, Denmark. vsb24knh@vibamt.dk

Acta Paediatrica (Oslo, Norway : 1992)

|August 2, 2003

Summary

Weekly oral vitamin K supplementation effectively prevented vitamin K deficiency bleeding (VKDB) in infants. Parental compliance with the oral vitamin K regimen was high, demonstrating its practicality for infant health.

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Area of Science:

Neonatal Health
Pediatric Pharmacology
Public Health Interventions

Background:

Vitamin K deficiency bleeding (VKDB) is a serious risk for newborns.
Traditional intramuscular vitamin K prophylaxis has been standard, but oral routes are explored for ease of administration.
Understanding the efficacy and compliance of oral vitamin K is crucial for neonatal care guidelines.

Purpose of the Study:

To evaluate the effectiveness of oral vitamin K prophylaxis in preventing VKDB.
To assess parental compliance with a weekly oral vitamin K regimen for infants up to 3 months of age.

Main Methods:

A large cohort study in Denmark involving over 500,000 live births.
Implementation of a 2 mg oral phytomenadione dose at birth, followed by weekly 1 mg doses administered by parents until 3 months for breastfed infants.
Surveillance for VKDB cases through pediatric department questionnaires and national patient register checks.

Main Results:

No cases of VKDB were identified, indicating an incidence of 0-0.9 per 100,000 live births.
Parental compliance was high, with 94% of infants completing the recommended prophylaxis course.
The study involved approximately 396,000 neonates receiving oral prophylaxis at birth.

Conclusions:

Weekly oral vitamin K supplementation is an effective prophylactic measure against VKDB in the first three months of life.
The oral route demonstrated good parental compliance, suggesting feasibility for widespread adoption.
This approach offers a viable alternative for VKDB prevention in newborns.