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Related Experiment Videos

Vaccinations in pregnancy.

Denise K Sur1, David H Wallis, Theodore X O'Connell

  • 1David Geffen School of Medicine, University of California-Los Angeles, California, USA. dsur@mednet.ucla.edu

American Family Physician
|August 2, 2003
PubMed
Summary

Misconceptions about vaccine safety hinder adult immunization. During pregnancy, routine vaccines like diphtheria and influenza are safe, while others like MMR are contraindicated to protect the fetus.

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Area of Science:

  • Immunology
  • Obstetrics
  • Public Health

Background:

  • Adult immunization rates are below national targets due to safety and benefit misconceptions.
  • These concerns are amplified during pregnancy, leading to physician hesitancy and patient reluctance regarding vaccinations.

Purpose of the Study:

  • To review the safety and indications of various vaccines during pregnancy.
  • To address misconceptions that may impede appropriate maternal immunization.

Main Methods:

  • Literature review of vaccine safety data in pregnant populations.
  • Categorization of vaccines based on safety profiles during gestation.
  • Analysis of risks versus benefits for maternal and fetal health.

Main Results:

  • Routine vaccines such as diphtheria, tetanus, influenza, and hepatitis B are generally safe for pregnant individuals.
  • Vaccines like measles, mumps, rubella (MMR), varicella, and bacille Calmette-Guerin (BCG) are contraindicated due to theoretical fetal risks.
  • Meningococcal and rabies vaccines may be considered based on individual risk assessment.

Conclusions:

  • Physicians and patients should be aware of which vaccines are safe and contraindicated during pregnancy.
  • Weighing theoretical vaccination risks against disease risks is crucial for informed decision-making.
  • Inadvertent administration of contraindicated vaccines does not warrant pregnancy termination.

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