Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Spatial control of exocytosis.

Elias T Spiliotis1, W James Nelson

  • 1Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA 94305-5435, USA.

Current Opinion in Cell Biology
|August 2, 2003
PubMed
Summary

Spatial control of exocytosis relies on membrane microdomains that organize molecular machinery for vesicle fusion. Signaling pathways further refine these sites, directing the secretory pathway for localized exocytosis.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Septins in the Middle-Makers and Breakers of Membrane Contact Sites.

Journal of neurochemistry·2026
Same author

Septin multimer autoantibodies in severe motor neuropathy mimicking lower motor neuron disease.

Brain : a journal of neurology·2026
Same author

Microtubule-templated actin assembly by septin9 drives apical expansion of epithelial cells.

bioRxiv : the preprint server for biology·2026
Same author

Septin crosstalk with microtubules and actin is regulated by a GSK3-dependent phosphoswitch.

bioRxiv : the preprint server for biology·2026
Same author

Septins buffer actomyosin forces to protect the nucleus from genotoxic mechanical stress.

bioRxiv : the preprint server for biology·2026
Same author

Septin-coated microtubules promote maturation of multivesicular bodies by inhibiting their motility.

The Journal of cell biology·2024

Area of Science:

  • Cell Biology
  • Molecular Biology
  • Biophysics

Background:

  • Exocytosis, a key biological process, is often spatially regulated at specific plasma membrane regions.
  • This spatial control is linked to changes in the membrane skeleton and the formation of local membrane microdomains.

Purpose of the Study:

  • To investigate the role of membrane microdomains in the spatial regulation of exocytosis.
  • To understand how molecular complexes and signaling pathways contribute to localized exocytosis.

Main Methods:

  • The study likely involved advanced microscopy techniques to visualize membrane dynamics.
  • Analysis of protein interactions and signaling events at the plasma membrane.

Main Results:

  • Membrane microdomains serve as platforms for assembling protein complexes (targeting patches) essential for vesicle-membrane fusion.
  • Local signaling pathway activation stabilizes these targeting patches.
  • These processes may guide the secretory pathway to specific exocytosis sites.

Conclusions:

  • Membrane microdomains and associated signaling are critical for spatially controlled exocytosis.
  • This regulation ensures efficient and targeted delivery of cellular cargo.

Related Experiment Videos