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Depression and obesity.

Albert J Stunkard1, Myles S Faith, Kelly C Allison

  • 1Weight and Eating Disorders Program, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA.

Biological Psychiatry
|August 2, 2003
PubMed
Summary
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Depression and overweight are common, but this study explores their functional link. Childhood adversity and genetics may influence their co-occurrence, impacting adult body mass index (BMI).

Area of Science:

  • Psychiatry
  • Public Health
  • Genetics

Background:

  • High prevalence of depression (10%) and overweight (65%) suggests potential co-occurrence.
  • The functional relationship between depression and overweight requires clarification.

Purpose of the Study:

  • To investigate the functional relationship between depression and overweight using moderator/mediator distinctions.
  • To identify factors influencing the co-occurrence of depression and overweight.

Main Methods:

  • Utilized moderator variables (e.g., depression severity, obesity severity, SES, gender, gene-environment interactions, childhood experiences).
  • Examined mediator variables (e.g., eating, physical activity, teasing, disordered eating, stress).
  • Analyzed the predictive relationship between adolescent depression and adult body mass index (BMI).

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Main Results:

  • Adolescent depression predicted higher adult BMI.
  • Obesity and depression are linked in women, especially in high SES groups.
  • Men show an inverse relationship between depression and obesity, unrelated to SES.
  • Genetic susceptibility and environmental factors, including adverse childhood experiences, appear to influence co-occurrence.

Conclusions:

  • Adverse childhood experiences and genetic predispositions may contribute to the co-occurrence of depression and obesity.
  • Further systematic research is needed to understand causal mechanisms for prevention and treatment.
  • The relationship between depression and obesity is complex and moderated by factors like gender and SES.