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Updated: Sep 20, 2026
Methods for the Discovery of Novel Compounds Modulating a Gamma-Aminobutyric Acid Receptor Type A Neurotransmission
Published on: August 16, 2018
Transfected cells for study of alcohol actions on GABA(A) receptors
1Denver VA Medical Center and Department of Pharmacology, University of Colorado School of Medicine, Denver, CO 80262, USA. harris@uchsc.edu
Abstract:
The ability to transfect and express foreign genes in cultured cells and Xenopus oocytes has contributed immensely to our knowledge of drug-receptor interactions and signal transduction following receptor activation. These techniques are now being used to study acute and chronic effects of ethanol on neurotransmitter receptors and cellular signaling. This article reviews the use of transfected cells to study ethanol actions on the GABAA receptor.
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