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Cutaneous nodular amyloidosis masquerading as a foot callus
Theresa A Borrowman1, Michael E Lutz, John S Walsh
1Deparment of Dermatology, Mayo Clinic, Rochester, Minnesota, USA.
Journal of the American Academy of Dermatology
|August 2, 2003
Summary
This study details a rare case of nodular primary localized cutaneous amyloidosis (PLCA) presenting as foot lesions. The condition was diagnosed after ruling out systemic amyloidosis, highlighting an unusual presentation.
Area of Science:
- Dermatology
- Pathology
Background:
- Primary localized cutaneous amyloidosis (PLCA) is a rare condition characterized by amyloid deposition in the skin.
- Nodular PLCA is a subtype that presents as distinct nodules or plaques.
Observation:
- A 69-year-old man presented with a year-long history of pink nodules and plaques on his right foot's sole, alongside a 30-year-old callus on his heel.
- Histopathology revealed amorphous, eosinophilic material deposits and plasma cell infiltrates in the dermis.
- Congo red staining showed characteristic apple-green birefringence under polarized light.
Findings:
- Extensive clinical and laboratory evaluations excluded systemic amyloidosis.
- The diagnosis of nodular primary localized cutaneous amyloidosis (PLCA) was established.
- The presentation was unusual due to its isolation to the pedal/plantar surfaces.
Implications:
- This case underscores the importance of considering localized cutaneous amyloidosis in pedal lesions.
- It highlights an uncommon presentation of nodular PLCA, emphasizing the need for thorough histopathological examination.
- Further review of nodular PLCA's origins and features is warranted.