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Neonatal pemphigus foliaceus.

Ranella Hirsch1, Judy Anderson, Jeffrey M Weinberg

  • 1Department of Dermatology, State University of New York Health Science Center at Brooklyn, Brooklyn, NY, USA.

Journal of the American Academy of Dermatology
|August 2, 2003
PubMed
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Neonatal pemphigus foliaceus is a rare condition where maternal antibodies cause blisters in newborns. This case highlights the passive transfer of these IgG antibodies across the placenta.

Area of Science:

  • Dermatology
  • Immunology
  • Neonatology

Background:

  • Pemphigus encompasses autoimmune diseases marked by skin/mucosal blisters and autoantibodies.
  • Neonatal pemphigus vulgaris has been documented, but neonatal pemphigus foliaceus is exceptionally rare.

Observation:

  • This report details only the second known case of neonatal pemphigus foliaceus.
  • The infant presented with characteristic blisters and erosions consistent with the condition.

Findings:

  • Pemphigus foliaceus antibodies are known to cross the placental barrier.
  • The disease in the neonate is attributed to the passive transfer of maternal IgG autoantibodies.

Implications:

  • This case underscores the importance of recognizing neonatal pemphigus foliaceus.

Related Experiment Videos

  • Understanding transplacental antibody transfer is crucial for diagnosing and managing this rare neonatal condition.