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Updated: Mar 3, 2026

A Patient-Derived Xenograft Model for Venous Malformation
Published on: June 15, 2020
[Arteriovenous malformation-glioma association: study of four cases]
Lia Raquel R Borges1, Suzana M F Malheiros, Maria Paula Pelaez
1Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, SP, Brasil. liaraquel.nepi@epm.br
Abstract:
We reviewed the clinical presentation, imaging and histopathologic findings in 4 patients with the diagnosis of arteriovenous malformation associated with glioma that were operated on from 1991 to 2000 in our institution. Four patients (2 males; age between 15 and 52 years) presented with progressive headache with clinical evidence of intracranial hypertension (in 3) and partial seizures (in 1). CT scan showed a brain tumor without any detectable pathologic vessels. Histologic examination revealed astrocytic tumors associated with arteriovenous malformation. No patient presented the vascular component intermixed with the tumor. The arteriovenous-glioma association is rare and must be identified by a clear demarcation between the malformation and the tumor.

