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Clinical importance of the genus Trichoderma. A review

L Kredics1, Zsuzsanna Antal, Ilona Dóczi

  • 1Microbiological Research Group, Hungarian Academy of Sciences, University of Szeged, P.O. Box 533, H-6701 Szeged, Hungary.

Acta Microbiologica Et Immunologica Hungarica
|August 5, 2003
PubMed

Insights

Opportunistic fungal infections caused by Trichoderma are increasing in immunocompromised patients. This review summarizes clinical cases and discusses antifungal susceptibility, ecophysiology, enzymology, and taxonomy of clinical Trichoderma isolates.

Area of Science:

  • Mycology
  • Clinical Microbiology
  • Infectious Diseases

Background:

  • Opportunistic fungal infections are a growing concern in immunocompromised populations.
  • The filamentous fungal genus Trichoderma, known for agricultural and biotechnological uses, is increasingly recognized for its clinical significance.
  • Recent data highlight Trichoderma species as potential opportunistic pathogens in vulnerable individuals.

Purpose of the Study:

  • To review and synthesize clinical case reports of Trichoderma infections.
  • To discuss the antifungal susceptibility profiles of clinical Trichoderma isolates.
  • To explore the ecophysiological, enzymological, and systematic characteristics of medically relevant Trichoderma strains.

Main Methods:

  • Comprehensive literature search for clinical case reports involving Trichoderma infections.
  • Systematic review of published data on antifungal susceptibility testing for Trichoderma.
  • Analysis of studies detailing the ecophysiology, enzymology, and taxonomy of clinical isolates.

Main Results:

  • Compilation of documented clinical cases of Trichoderma infections in humans.
  • Summary of current knowledge regarding the sensitivity and resistance of Trichoderma to various antifungal agents.
  • Overview of the biological and genetic features distinguishing clinical Trichoderma isolates.

Conclusions:

  • Trichoderma represents an emerging opportunistic fungal pathogen in immunocompromised hosts.
  • Understanding antifungal susceptibility is crucial for effective treatment of Trichoderma infections.
  • Further research into the clinical aspects of Trichoderma is warranted to improve patient outcomes.

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