Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Left ventricular mass regression in elderly hypertensives.

G Gerstenblith1

  • 1Johns Hopkins Hospital, Baltimore, Maryland 21205.

Journal of Human Hypertension
|December 1, 1992
PubMed
Summary

Verapamil effectively controlled blood pressure and reduced left ventricular mass in elderly patients with hypertension. This regression positively impacted diastolic function and cardiac performance.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

AHA Conference Proceedings: Do existing databases hold the answers to clinical questions in geriatric cardiovascular disease and stroke? Executive Summary. Database Conference, January 27-30, 2000. Washington, DC, USA.

Circulation·2001
Same author

Database Conference January 27-30, 2000, Washington D.C.--Do existing databases answer clinical questions about geriatric cardiovascular disease and stroke?

The American journal of geriatric cardiology·2001
Same author

Thrombolytic therapy and mortality.

Lancet (London, England)·2001
Same author

Upregulation of the nitric oxide-cGMP pathway in aged myocardium: physiological response to l-arginine.

Circulation research·2001
Same author

Spot urinary albumin-creatinine ratio predicts left ventricular hypertrophy in young hypertensive African-American men.

American journal of hypertension·2000
Same author

Consequences of vascular aging: concepts for the clinician.

Italian heart journal : official journal of the Italian Federation of Cardiology·2000

Area of Science:

  • Cardiology
  • Geriatrics
  • Pharmacology

Background:

  • Left ventricular hypertrophy (LVH) is a recognized risk factor for coronary disease in the elderly.
  • The impact of antihypertensive agents on LVH regression and subsequent cardiac function in older adults is not well understood.

Purpose of the Study:

  • To compare verapamil and atenolol in controlling blood pressure and inducing LVH regression in elderly hypertensives.
  • To assess the effect of LVH regression on diastolic filling and cardiac performance.

Main Methods:

  • 42 hypertensive patients (≥60 years) underwent echocardiography and blood pool scans.
  • Randomized trial comparing verapamil and atenolol, with chlorthalidone as add-on therapy.
  • Measurements repeated after 6 months and medication withdrawal.

Main Results:

  • Verapamil achieved blood pressure control alone in 18 patients; atenolol alone in 8 (p < 0.01).
  • LV mass regression and improvements in diastolic filling and ejection fraction were observed with verapamil.

Conclusions:

  • Verapamil demonstrates superior efficacy in blood pressure control and LVH regression compared to atenolol in the elderly.
  • LVH regression induced by verapamil improves diastolic relaxation and cardiac output in older hypertensive patients.

Related Experiment Videos