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The antihypertensive effect of verapamil in patients with chronic renal failure

J L Rodicio1, J M Alcazar, L M Ruilope

  • 1University of Madrid, Hospital 12 de Octubre, Spain.

Journal of Human Hypertension
|December 1, 1992
PubMed

Insights

Verapamil effectively reduces hypertension in chronic renal failure patients, regardless of sodium intake. It also helps manage proteinuria, making it a valuable treatment option.

Area of Science:

  • Nephrology
  • Cardiology
  • Pharmacology

Background:

  • Hypertension is a common complication in chronic renal failure (CRF).
  • Dietary sodium and protein intake can influence blood pressure and proteinuria in CRF patients.
  • Calcium channel blockers, like verapamil, are used to manage hypertension.

Purpose of the Study:

  • To evaluate the efficacy of verapamil-SR in reducing hypertension in CRF patients on varying sodium diets.
  • To assess the impact of verapamil-SR on proteinuria in CRF patients on normal and low-protein diets.

Main Methods:

  • A study involving patients with chronic renal failure and hypertension.
  • Administration of verapamil-SR 240 mg daily.
  • Monitoring of blood pressure and proteinuria levels under different dietary conditions (low/high sodium, normal/low protein).

Main Results:

  • Verapamil-SR (240 mg daily) effectively reduced hypertension in CRF patients.
  • The antihypertensive effect of verapamil was consistent across both high and low sodium intake groups.
  • Verapamil-SR helped maintain reduced proteinuria in CRF patients on low-protein diets and showed potential in preventing proteinuria in those on normal-protein diets.

Conclusions:

  • Verapamil-SR 240 mg daily is an effective treatment for hypertension in chronic renal failure patients.
  • Its efficacy is not affected by sodium intake levels.
  • Verapamil-SR demonstrates beneficial effects on proteinuria management in CRF patients, particularly those on protein-restricted diets.

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